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This research, not long ago won the city's second prize for scientific and technological progress.
Half of obesity is genetically caused. "Little chubby piers are indeed more and more. People are now talking about obesity as much as talking about the weather." Guo Xirong told reporters that in the 1980s and 1990s, experts from the China Children's Health Association had conducted nationally. Two epidemiological surveys of childhood obesity alone found that the detection rate of simple obesity in children in China was only 0.91% in 1986, and it rose to 2.0% in 1996. The national average annual growth rate was as high as 9.1%. It also means that the number of obese children has doubled in 10 years. The Ministry of Health conducted a school health survey and the results also showed that about 12.2% of first-year primary school students and 12.8% of sixth-grade primary school students have obesity problems.
According to experts, the latest research shows that obesity is a polygenic hereditary disease. There are more than 200 genes or chromosomal regions associated with obesity. The "contribution rate" of genetics to obesity accounts for 40% to 60%, and about half of obesity. It is determined by genetics.
Newly Discovered Obesity Genes In order to understand which genetic genes control the occurrence of obesity, experts have used the “Gene Expression Profile†method to study all relevant genetic information.
In the study, experts extracted retroperitoneal adipose tissue from obese and normal-weight individuals and established a “gene expression profile†of retroperitoneal adipose tissue in obese and normal-weight individuals. Experts also used a high-fat diet to allow normal rats to eat obese rats and to investigate the relationship between obesity-related genes through gene therapy. Through these studies, the experts discovered a large number of new genes, mechanisms, or known genes that may be involved in the development of obesity, and provided new clues for obesity research. Experts also discovered for the first time five new genes that were accepted and published by NCBI (National Center for Biotechnology Information) Genetic Bank.
Studies have confirmed that oolong tea helps to lose weight According to gene expression profiles, experts have conducted in-depth studies on the relationship between calcium metabolism intervention and obesity. The results showed that the appropriate amount of calcium in the diet can indeed inhibit the occurrence of obesity, and the oolong tea extract also has a certain weight loss effect.
In the mouse trial, experts also set up a normal diet group, a high-fat and low-dose oolong tea extract diet group, a high-fat and medium-dose oolong tea extract diet group, and a high-fat and high-dose oolong tea extract diet group. The results confirmed that oolong tea did Has a good weight loss effect, in which the middle dose group has the best effect.
Experts frankly stated that there is currently no cure for obesity in the world. Diet and exercise treatments have little effect; surgical treatment tends to rebound; although some weight loss drugs claim to have special effects, there are currently no specific drugs. The genetic code for obese genetics, which has been deciphered by experts, has provided a new “target†for the treatment of obesity-related genetic drugs, allowing drugs to reach the “nest†of obese genes and targeting people to solve the obesity problem.
Why are more chubby piers? Why do some people not eat fat? Why does exercise rebound once it stops? In order to open up this series of question marks, Guo Xirong, the deputy dean of the Nanjing Maternal and Child Health Hospital affiliated to Nanjing Medical University, led the project team to discover and report on obesity and obesity at home and abroad for the first time through the construction of obesity-related gene expression profiles in humans and rats. Related new genes and functions, known genes in obesity, new functions and new mechanisms.